Windows 7 Desktop Icons don't work

I have windows 7 ultimate signature edition, from being a windows 7 launch party host.

every once in a while my desktop icon, are not clickable.  I can click on shortcuts on the bottom bar and the windows ball at the bottom to load programs from the start menu, but no shortcuts on the desktop will work. I can not even click on the widget on the side of my desktop

Everything works again when a do a reboot, and will be fine for a few days then it happens again.

This is the 5th time it has happen since installing windows 7  three weeks ago.